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Effects in active malignancy are not well characterized, and most clinicians treat this as an exclusion until more data exists

Clinical studies show significant reduction in pigmentation intensity after 12 weeks of consistent use, with some users seeing improvements as early as 4-6 weeks

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The primary processes of paraquat toxicity involve the production of reactive oxygen species and the cellular release of nicotinamide adenine dinucleotide phosphate (NADPH) 27